Pharmacokinetics of progesterone after its administration to ovariectomized rhesus monkeys by injection, infusion, or nasal spraying.

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Abstract
The pharmacokinetics of progesterone (dose:10 .mu.g per animal) were studied in blood and CSF of adult ovariectomized rhesus monkeys after the administration of the steroid as an i.v. injection, i.v. infusion (duration of infusion: 10 min) or nasal spray. The bioavailability of progesterone, in terms of area under the time-concentration curve and the maximal concentration in the 2 body fluids, was significantly higher when the steroid was infused or sprayed intranasally than when it was injected i.v. The clearance of the steroid from the serum, as estimated by its elimination rate constant, elimination half-life and total body clearance, did not differ for the 3 methods of administration. The bioavailability of progesterone apparently is enhanced by extending the duration over which the steroid is delivered into the hemal circulation.