Lectin-binding sites in eccrine sweat gland tumours

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Abstract
Lectin‐binding sites in sections of formalin‐fixed, paraffin‐embedded eccrine sweat gland tumours were investigated using fluorescein isothiocyanate (FITC) conjugated peanut agglutinin (PNA), FITC conjugated Ricinus communis 1 agglutinin (RCA‐1) and FITC conjugated wheat germ agglutinin (WGA). In 22 benign eccrine sweat gland tumours, lectin‐binding sites were noted primarily on the cell surface, and in the secretions. In five malignant sweat gland tumours, all showed cytoplasmic lectin‐binding sites in variable proportions of malignant cells in addition to cell surface staining. These results indicate that cytoplasmic lectin‐binding sites may be a useful marker of neoplastic transformation of eccrine sweat gland tumours.
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