Organisation of the murine 5‐HT3 receptor gene and assignment tohuman chromosome 11
- 21 February 1994
- journal article
- Published by Wiley in FEBS Letters
- Vol. 339 (3) , 302-306
- https://doi.org/10.1016/0014-5793(94)80435-4
Abstract
We have isolated the murine gene encoding the 5‐HT3 receptor (5‐HT3R), a member of the ligand‐gated ion channels, that mediates a variety of physiological effects in central and peripheral neurons. DNA sequence analysis of the 5‐HT3R gene revealed its organisation in 9 exons distributed over approximately 12 kbp of DNA. Alternative use ofexon 9 splice acceptor sites generated two 5‐HT3R variants. The 5‐HT3R gene, whose structure is closely related to neuronal and muscle AChRα genes, as demonstrated by four common splice junctions, was localised on human chromosome 11.Keywords
This publication has 43 references indexed in Scilit:
- NIGMS Human/Rodent Somatic Cell Hybrid Mapping Panels 1 and 2Genomics, 1993
- Cloning and fnctional expression of an apparent splice variant of the murine 5-HT3 receptor A subunitEuropean Journal of Pharmacology: Molecular Pharmacology, 1993
- A Comprehensive Genetic Linkage Map of the Human GenomeScience, 1992
- Recent advances in the electrophysiological characterization of 5-HT3 receptorsTrends in Pharmacological Sciences, 1992
- Clinical evaluation of 5-HT3 receptor antagonists as anti-emeticsTrends in Pharmacological Sciences, 1991
- Conserved Organization of ?-Aminobutyric AcidAReceptor Genes: Cloning and Analysis of the Chicken ?4-Subunit GeneJournal of Neurochemistry, 1991
- Location of a threonine residue in the α -subunit M2 transmembrane segment that determines the ion flow through the acetylcholine receptor channelProceedings Of The Royal Society B-Biological Sciences, 1991
- A neuronal nicotinic acetylcholine receptor subunit (α7) is developmentally regulated and forms a homo-oligomeric channel blocked by α-BTXNeuron, 1990
- Assembly of an adult type acetylcholine receptor in a mouse cell line transfected with rat muscle ϵ‐subunit DNAFEBS Letters, 1990
- Site-directed mutagenesis by overlap extension using the polymerase chain reactionGene, 1989