A comparison of three affected‐sib‐pair scoring methods to detect HLA‐linked disease susceptibility genes
- 1 May 1984
- journal article
- research article
- Published by Wiley in American Journal of Medical Genetics
- Vol. 18 (1) , 135-146
- https://doi.org/10.1002/ajmg.1320180117
Abstract
Two widely used affected‐sib‐pair scoring procedures (the Green and Woodrow [1977] procedure, and the method of forming all possible affected‐sib‐pairs) are compared with a new method for their relative efficiency in detecting the presence of an HLA‐linked disease susceptibility gene. Their relative performance is investigated by extensive computer simulations over a large number of disease transmission models. On the average, the new procedure appears to outperform the Green and Woodrow method and the “all‐possible‐pairs” method.Keywords
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