EFFECTS OF RENIN IN RATS TREATED WITH METHYLANDROSTENEDIOL

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Abstract
Methylandrostenediol is shown to elicit hypertension and hypertensive vascular lesions in uninephrectomized, salt-fed rats. This hypertensive state resembles the type of hypertension produced by injections of anterior pituitary extracts; both are associated with degenerative changes in the adrenals. The droplets which form in the adrenal cortex react histochemically as muco- or glyco-proteins. Unlike desoxycorticosterone or the adrenal steroids, cortisone and hydrocortisone, MAD does not sensitize to the acute vasculotoxic effects of subcutaneously injected renin. The mechanism of MAD hypertension is distinct from that of DCA hypertension. It may represent an indirect response, possibly mediated by renin, to the stimulus of excessive renal growth.