Bactericidal Efficacy of Metronidazole against Bacteria of Human Carious Dentin in vitro

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Abstract
The bactericidal efficacy of metronidazole against bacteria in carious dentin was clarified by measuring (1) the difference between bacterial recovery from suspensions of carious dentin on metronidazole-containing BHI-Blood agar plates (10 μg/ml) and control plates and (2) the difference between bacterial recovery from carious lesions of freshly extracted teeth, covered by α-tricalcium phosphate (TCP) cement containing metronidazole (5%) for 1–3 days and that covered by TCP only. More than 103 bacteria per milligram sample were recovered from carious dentin. More than 99% of the bacteria were, however, not recovered when samples were inoculated on metronidazole-containing BHI-Blood agar plates or when the lesions were covered by TCP cement containing metronidazole, indicating that metronidazole effectively disinfected the carious dentin.

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