Genetic Mapping of Loci for Glucose-6-Phosphate Dehydrogenase, Gluconate-6-Phosphate Dehydrogenase, and Gluconate-6-Phosphate Dehydrase in Escherichia coli

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Abstract
The loci on the Escherichia coli genome of mutations affecting the constitutive enzymes glucose-6-phosphate dehydrogenase ( zwf ) and gluconate-6-phosphate dehydrogenase ( gnd ), and the inducible enzyme gluconate-6-phosphate dehydrase ( edd ), were determined by conjugation and transduction experiments, chiefly by three-factor crosses. They are in the same region of the chromosome, and their order is gnd—his— ( edd, zwf ) —aroD; gnd and his are cotransduceable, as are zwf and edd . The position of gnd in Salmonella typhimurium was shown to be similar to that in E. coli .