Brain Serotonin 5-HT1A Receptor Binding in Schizophrenia Measured by Positron Emission Tomography and [11C]WAY-100635
Open Access
- 1 June 2002
- journal article
- research article
- Published by American Medical Association (AMA) in Archives of General Psychiatry
- Vol. 59 (6) , 514-520
- https://doi.org/10.1001/archpsyc.59.6.514
Abstract
THERE IS CONSIDERABLE evidence for a role of the neurotransmitter serotonin(5-hydroxytryptamine [5-HT]) in the pathophysiologic characteristics of schizophrenia.1-3 Recent interest in 5-HT has been fueled by the fact that novel antipsychotic drugs such as clozapine, olanzapine, quetiapine, risperidone, sertindole, and ziprasidone hydrochloride are potent 5-HT2A receptor antagonists and relatively weaker dopamine D2 antagonists.4 In addition, 5-HT1A and 5-HT2C receptors seem to contribute to the clinical effects of some novel antipsychotic drugs.5Keywords
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