Polypeptide constitution of receptors for apamin, a neurotoxin which blocks a class of Ca2+‐activated K+ channels
- 8 May 1989
- journal article
- Published by Wiley in FEBS Letters
- Vol. 248 (1-2) , 150-154
- https://doi.org/10.1016/0014-5793(89)80451-x
Abstract
Affinity labelling experiments with different azido‐125I‐apamin derivatives were carried out to identify polypeptide components of the apamin‐sensitive Ca2+‐activated K+ channel in brain and pheochromocytoma cell membranes. Different polypeptides were labelled with different apamin derivatives. The major component has a molecular mass of about 30 kDa but other components at 45, 58 and 86 kDa were also identified. Results obtained with brain membranes on one hand and pheochromocytoma cells on the other were not exactly identical and suggest that there are sub‐types of apamin receptors.Keywords
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