General and Versatile Approach to the Synthesis of Optically Active 5- Alkylpiperazine-2-carboxylic Acids

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Abstract
General and convenient syntheses of optically active 5-alkylpiperazine-2-carboxylic acids are described. The methods are based on cyclization of L- or D-serine with α-amino acids and occur without loss of optical purity. The presented procedures are based on readily available starting materials and can be arranged for multigram quantities.

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