Some effects of mianserin on monoamine metabolism in the rat brain.
- 1 February 1978
- journal article
- Published by Wiley in British Journal of Clinical Pharmacology
- Vol. 5 (S1) , 11S-12S
- https://doi.org/10.1111/j.1365-2125.1978.tb04568.x
Abstract
1 Mianserin does not affect the uptake of biogenic amines into rat brain, in contrast to tricyclic antidepressants which block amine uptake. 2 Mianserin increases the turnover of noradrenaline (NA) in rat brain after acute or chronic administration, whereas tricyclic antidepressants reduce turnover of NA and 5-hydroxytryptamine. 3 It should not be assumed that a compound must inhibit amine re-uptake mechanisms before it can be considered as a potential antidepressant.This publication has 9 references indexed in Scilit:
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