GLUCAGON ADMINISTRATION DECREASES HEPATIC NUCLEAR TRIIODOTHYRONINE BINDING CAPACITY

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Abstract
The maximal binding capacity (MBC) of nuclear triiodothyronine (T3) receptor sites in rat liver decreases markedly after glucagon administration. Administration of serial doses of glucagon (2.5 .mu.g/100 g body wt) resulted in a 33% decrease in MBC in 3.5 h and MBC was reduced by 45% in 6.25 h. The individual doses used were in the same order of magnitude as those used in the treatment of hypoglycemic human subjects (1.5 .mu.g/100 g body wt). This report presents the 1st evidence that a peptide hormone can change the number of nuclear T3 receptor sites. The physiological significance of these findings remains to be clarified.