Interaction between imipramine-like agents and catecholamine-induced hyperthermia

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Abstract
Imipramine-like drugs potentiate the hyperthermic response obtained by infusion of noradrenaline, adrenaline and isoprenaline. In addition to this effect, desipramine increases the hyperthermic response induced by L-dopa (in monoamine oxidase blocked rats), reserpine (immediately after intravenous injection) and dexamphetamine. On the contrary, other types of hyperthermia, such as the one induced by phenethylamine in monoamine oxidase treated rats, and that by yeast, were not increased by desipramine. These results are discussed in relation to the mechanism of action of antidepressant drugs.