Effect of Sustained, Graded Urea Diuresis on Water and Electrolyte Excretion

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Abstract
Renal water and electrolyte excretion were studied in the dog during prolonged (5-8 hours) urea diuresis. In the average experiment electrolyte comprises about 1/3 of the osmotically active urinary solute. Bicarbonate excretion increases more slowly than chloride with increasing urea load. K: creatinine clearance ratios greater than 1.0 were observed frequently during urea but never during mannitol diuresis, irrespective of plasma Na or K concentrations. Following urea loading the urine temporarily exhibits a hypotonicity which is refractory to Pitressin injection. Measurements of renal tubular concentrating power and of filtration rate changes during urea diuresis are given.