Bright Fluorescent Nanodiamonds: No Photobleaching and Low Cytotoxicity
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- 25 November 2005
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of the American Chemical Society
- Vol. 127 (50) , 17604-17605
- https://doi.org/10.1021/ja0567081
Abstract
Diamond nanocrystals emit bright fluorescence at 600−800 nm after irradiation by a 3 MeV proton beam (5 × 1015 ions/cm2) and annealing at 800 °C (2 h) in vacuum. The irradiation/annealing process yields high concentrations of nitrogen-vacancy defect centers (∼107 centers/μm3), making possible visualization of the individual 100 nm diamond crystallites using a fluorescence microscope. The fluorescent nanodiamonds (FND) show no sign of photobleaching and can be taken up by mammalian cells with minimal cytotoxicity. The nanomaterial can have far-reaching biological applications.Keywords
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