Mutation Theory of Carcinogenesis in Retinoblastoma2
- 1 August 1976
- journal article
- research article
- Published by Oxford University Press (OUP) in JNCI Journal of the National Cancer Institute
- Vol. 57 (2) , 269-276
- https://doi.org/10.1093/jnci/57.2.269
Abstract
To test Knudson's hypothesis that two successive mutations are involved in retinoblastoma, we studied the data on 899 cases. Some of the findings appeared to differ from those that might be expected if Knudson's hypothesis were correct. Certain criticisms of Knudson's methodology and model were suggested. Alternative explanations proposed were 1) the role of the sequence in which mutations occur, and 2) the possibility of three mutational events.Keywords
This publication has 1 reference indexed in Scilit:
- Natural and radiation carcinogenesis in man I. Theory of initiation phaseProceedings of the Royal Society of London. B. Biological Sciences, 1965