The role of CD28 and cytotoxic T‐lymphocyte antigen‐4 (CTLA‐4) in regulatory T‐cell biology
Top Cited Papers
- 21 July 2006
- journal article
- review article
- Published by Wiley in Immunological Reviews
- Vol. 212 (1) , 131-148
- https://doi.org/10.1111/j.0105-2896.2006.00419.x
Abstract
The profound influence of CD28 and cytotoxic T-lymphocyte antigen-4 (CTLA-4) on T-cell immunity has been known for over a decade, yet the precise roles played by these molecules still continue to emerge. Initially viewed as molecules that provide cell-intrinsic costimulatory and inhibitory signals, recent evidence suggests that both CD28 and CTLA-4 are also important in the homeostasis and function of a population of suppressive cells, termed regulatory T cells (Tregs). Here we review the main features of the CD28 and CTLA-4 system and examine how these impact upon Treg biology.Keywords
This publication has 160 references indexed in Scilit:
- Hassall's corpuscles instruct dendritic cells to induce CD4+CD25+ regulatory T cells in human thymusNature, 2005
- Promiscuous gene expression in thymic epithelial cells is regulated at multiple levelsThe Journal of Experimental Medicine, 2005
- Toll-like receptor control of the adaptive immune responsesNature Immunology, 2004
- B7-1 and B7-2 Selectively Recruit CTLA-4 and CD28 to the Immunological SynapseImmunity, 2004
- In Vivo Instruction of Suppressor Commitment in Naive T CellsThe Journal of Experimental Medicine, 2004
- An Autoimmune Disease-Associated CTLA-4 Splice Variant Lacking the B7 Binding Domain Signals Negatively in T CellsImmunity, 2004
- Negative Regulation of T Cell Receptor–Lipid Raft Interaction by Cytotoxic T Lymphocyte–associated Antigen 4The Journal of Experimental Medicine, 2003
- Role of CD28 co-stimulation in generation and maintenance of virus-specific T cellsInternational Immunology, 2002
- Interleukin‐10 differentially regulates B7‐1 (CD80) and B7‐2 (CD86) expression on human peripheral blood dendritic cellsEuropean Journal of Immunology, 1995
- Ligation of CD28 receptor by B7 induces formation of D‐3 phosphoinositides in T lymphocytes independently of T cell receptor/CD3 activationEuropean Journal of Immunology, 1993