Effect of Colchicine on Antibody Response in Hamsters

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Abstract
The adjuvant effect of colchicine was investigated in the hamster primarily because this species is unique in tolerating high dosage of colchicine. Administration of non-toxic doses of colchicine (1 to 25 mg/kg body weight) enhanced hemagglutinin response to rabbit erythrocytes, but the increase in antibody response was no greater than that reported for the rabbit, a species far more susceptible to the toxicity of colchicine. The increased level of hemagglutinin was for complete antibody; levels of incomplete antibody were not elevated. Increase in the dose of colchicine to near-lethal levels (300 to 500 mg/kg) resulted in considerable reduction in antibody response.