Endothelin production in sepsis and the adult respiratory distress syndrome
- 1 January 1996
- journal article
- research article
- Published by Springer Nature in Intensive Care Medicine
- Vol. 22 (1) , 52-56
- https://doi.org/10.1007/bf01728331
Abstract
Septic shock is characterised by a decrease in systemic vascular resistance. Nevertheless, regional increases in vascular resistance can occur which may predispose to organ dysfunction, including the adult respiratory distress syndrome (ARDS). Because endothelial damage is a major feature of acute lung injury, we examined whether the potent endothelial vasoconstrictor peptide endothelin-1 plays a pathophysiological role in sepsis of ARDS.Keywords
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