Diphyllin, a Novel and Naturally Potent V-ATPase Inhibitor, Abrogates Acidification of the Osteoclastic Resorption Lacunae and Bone Resorption
Open Access
- 1 October 2007
- journal article
- research article
- Published by Oxford University Press (OUP) in Journal of Bone and Mineral Research
- Vol. 22 (10) , 1640-1648
- https://doi.org/10.1359/jbmr.070613
Abstract
Dissolution of the inorganic phase of bone by the osteoclasts mediated by V‐ATPase and ClC‐7 is a prerequisite for bone resorption. Inhibitors of osteoclastic V‐ATPase or ClC‐7 are novel approaches f...Keywords
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