COMPARISON OF [H-3] NICOTINE AND [H-3] ACETYLCHOLINE BINDING IN MOUSE-BRAIN - REGIONAL DISTRIBUTION

  • 1 January 1985
    • journal article
    • research article
    • Vol. 48  (3) , 345-352
Abstract
In a continuing study of nicotine binding sites, the relative amount of nicotine binding and acetylcholine binding in various brain regions of C57/BL and of DBA mice was determined. Although midbrain showed the highest and cerebelum the lowest binding for both [3H]nicotine and [3H]acetylcholine, the ratio of nicotine to acetylcholine binding showed a 3-fold regional variation. Acetylcholine inhibition of [3H]nicotine binding indicated that a portion of nicotine binding was not inhibited by acetylcholine. Important differences between the binding of (.+-.)-[3H]nicotine and that of [3H]acetylcholine are indicated.

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