Comparison of 99Tcm-pyrophosphate, 201Tl perfusion, 123I-labelled methyl-branched fatty acid and sympathetic imaging in acute coronary syndrome

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Abstract
Among a group of patients (n=15) with acute coronary syndrome, the results of using two new myocardial radiopharmaceuticals - 123l-labelled 15-(p-iodo-phenyl)-3,R,S-methylpentadecanoic acid (BMIPP) and 123l-meta-iodobenzyl guanidine (MIBG) - were compared with dual 201Tl/99Tcm-pyrophosphate (Tl-PYP) imaging using single photon emission tomography (SPET). Defect scores were evaluated on a segment-by-segment basis for a total of 270 segments. For the 201Tl, BMIPP, and early and delayed MIBG studies, the mean (± S.D.) sums of defect scores were 9 ± 8, 18 ± 9, 22 ± 12 and 29 ± 9, respectively, revealing significantly higher scores for BMIPP and MIBG than 201Tl (P
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