Infectious mononucleosis in children. Evaluation of Epstein-Barr virus-specific serological data
- 21 February 1977
- journal article
- research article
- Published by American Medical Association (AMA) in JAMA
- Vol. 237 (8) , 781-785
- https://doi.org/10.1001/jama.237.8.781
Abstract
Epstein-Barr virus (EBV)-specific antibody responses were determined in 43 consecutive pediatric patients who had signs and symptoms of infectious mononucleosis (IM) and positive diagnostic tests for mononucleosis (Monospot). Patients (30) gave clear-cut serologic evidence of primary EBV infections; of the remaining 13 patients, 7 had no antibodies to EBV in the acute- or convalescent-phase sera and 6 showed serologic patterns of past EBV infections. Further testing proved that the initial Monospot results were either false-positive or were incorrectly interpreted in all 13 patients with unidentifiable illnesses but in only 2 of the patients with current EBV infections. The data confirm the occurrence of classical IM in children and show that the disease and the EBV-specific antibody responses can be virtually indistinguishable from adult cases.This publication has 1 reference indexed in Scilit:
- Immunofluorescence in Cells Derived from Burkitt's LymphomaJournal of Bacteriology, 1966