99mTc-propylene amine oxime (99mTc-PnAO); a potential brain radiopharmaceutical
- 1 November 1984
- journal article
- research article
- Published by Springer Nature in European Journal of Nuclear Medicine and Molecular Imaging
- Vol. 9 (11) , 511-516
- https://doi.org/10.1007/bf00263256
Abstract
Propylene amine oxime (PnAO) forms a neutral lipid soluble complex with 99mTc. 99mTc-PnAO can be prepared by simple reduction of 99mTc-pertechnetate with stannous ion in the presence of excess PnAO in saline at or near neutral pH. This agent will passively penetrate biological membranes including the intact blood-brain barrier (BBB) as evidenced by the high brain uptake observed shortly after IV injection. The first-pass extraction efficiency in baboons was estimated to be 80% at normal blood flow. This agent or a derivatized form of 99mTc-PnAO may be useful in assessment of regional cerebral blood flow (rCBF) in humans.Keywords
This publication has 21 references indexed in Scilit:
- A neutral lipophilic complex of 99mTc with a multidentate amine oximeThe International Journal of Applied Radiation and Isotopes, 1984
- Reversed-phase HPLC of [99mTc]tetraamine complexesThe International Journal of Applied Radiation and Isotopes, 1984
- Radioiodine-labeled N,N-dimethyl-N'-[2-hydroxy-3-alkyl-5-iodobenzyl]-1,3-propanediamines for brain perfusion imagingJournal of Medicinal Chemistry, 1983
- N-isopropyl(I-123)p-iodoamphetamine brain scans with single-photon emission tomography: discordance with transmission computed tomography.Radiology, 1982
- Study of Cerebral Function with Positron Computed TomographyJournal of Cerebral Blood Flow & Metabolism, 1982
- Regional cerebral blood flow in stroke by 133Xenon inhalation and emission tomography.Stroke, 1981
- Relationship of octanol/water partition coefficient and molecular weight to rat brain capillary permeabilityJournal of Medicinal Chemistry, 1980
- A Single Photon Dynamic Computer Assisted Tomograph (DCAT) for Imaging Brain Function in Multiple Cross SectionsJournal of Computer Assisted Tomography, 1980
- A short and nearly symmetrical intramolecular hydrogen bond: x-ray and neutron diffraction analysis of 2,2-(1,3-diaminopropane)bis(2-methyl-3-butanone oximato)nickel(II) chloride hydrateInorganic Chemistry, 1979
- Macrocyclic effect on the stability of copper(II) tetramine complexesJournal of the American Chemical Society, 1969