Molecular aspects of sex determination in mice: an alternative model for the origin of the Sxr region
- 1 December 1988
- journal article
- research article
- Published by The Royal Society in Philosophical Transactions of the Royal Society of London. B, Biological Sciences
- Vol. 322 (1208) , 119-124
- https://doi.org/10.1098/rstb.1988.0119
Abstract
Using a combination ofin situmapping and DNA analysis with recombinant DNA probes specific for the Sxr region of the mouse Y chromosome, we show that both the gene(s) controlling primary sex determination and the expression of the male-specific antigen H-Y (TdyandHyarespectively) are located on the minute short arm of the mouse Y chromosome. We demonstrate that the H-Y-variant of Sxr (Sxr') arose by a partial deletion within the Sxr region and propose an alternative model for the generation of the original Sxr region.This publication has 14 references indexed in Scilit:
- Molecular cloning and sequence analysis of a mouse Y chromosome RNA transcript expressed in the test isNucleic Acids Research, 1987
- GENETIC CONTROL OF PRIMARY SEX DETERMINATION IN MICEAnnual Review of Genetics, 1986
- High frequency of unequal recombination in pseudoautosomal region shown by proviral insertion in transgenic mouseNature, 1986
- The structural gene coding for myelin-associated proteolipid protein is mutated in jimpy miceNature, 1986
- Spermatogenic failure in male mice lacking H–Y antigenNature, 1986
- Male sexual differentiation in mice lacking H–Y antigenNature, 1984
- A technique for radiolabeling DNA restriction endonuclease fragments to high specific activityAnalytical Biochemistry, 1984
- Meitoic crossing-over between the X and Y chromosomes of male mice carrying the sex-reversing (Sxr) factorNature, 1982
- Sex reversal in the mouseCell, 1982
- THE MURINE Y CHROMOSOME AS A MARKERTransplantation, 1966