Variation in response of Schistosoma mansoni strains to schistosomicides

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Abstract
The BH strain of Schistosoma mansoni was found to be highly susceptible to hycanthone (1 .times. 80 mg/kg), oxamniquine (1 .times. 100 mg/kg) niridazole (5 .times. 100 mg/kg), praziquantel (1 .times. 100 mg/kg), oltipraz (5 .times. 125mg/kg) and amoscanate (1 .times. 300 mg/kg) and is therefore a good reference strain for chemotherapeutic trials. By contrast, the MPR-1 strain was shown to have developed resistance to oxamniquine without ever having been dosed with oxamniquine. Other oxamniquine/hycanthone resistant strains were shown to have maintained their resistance and a strain believed to be partially resistant to oltipraz was evaluated.

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