STUDIES WITH AN ADRENAL INHIBITOR IN ADRENAL CARCINOMA*

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Abstract
The production of steroids in a case of widely disseminated adrenal carcinoma was studied with SU-4885. There was a striking decrease of both C19- and C21-11-oxygenated steroids in the urine with a concomitant increase in the corresponding 11-deoxy derivatives. The results support the view that the tumor and its metastases were responsive to ACTH and that there was increased steroid production during treatment with SU-4885. The isolation and characterization by partial synthesis of pregnane-3α, 17α, 20α, 21-tetrol and its 20β epimer (reduced derivatives of Reichstein's substance S) are reported. The isolation of pregnane-3α, 11β, 17α, 20α-tetrol but not of 11-ketopregnane-3α, 17α, 20α-triol from the urine of a patient with adrenal carcinoma is noted.