Neurotropic melanoma of the vulva

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Abstract
A spindle cell melanoma of the clitoris was associated with a large area of lentiginous melanocytic dysplasia in the vulva of a 51-year-old woman. There was extensive neoplastic infiltration of the dermis, a desmoplastic reaction, and replacement of perineurial and Schwann cells by tumor cells (neurotropism). The superficial dysplastic components were pigmented, but melanosomes were not identified in a lymph node metastasis. Here the internuclear areas strongly resembled neuropil. Vulvar melanoma is rare, and this is the first report of neurotropic melanoma in this site.