Preparation of some novel S-nitroso compounds as potential slow-release agents of nitric oxide in vivo
- 1 January 1994
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Perkin Transactions 1
- No. 7,p. 797-805
- https://doi.org/10.1039/p19940000797
Abstract
The optimum conditions for the preparation of N-acetyl-S-nitrosopenicillamine (SNAP)3 were determined and applied to the synthesis of the corresponding N-formyl compound 7. The nitrosation of penicillamine dipeptides was investigated and bis-thionitroso compounds 13, 18, 26 and 27 were isolated. S, S′-Dinitroso dithiol 13 showed biological activity akin to that of glyceryl trinitrate in decreasing systemic arterial blood pressure in anaesthetized rats and rabbits. Concomitant inhibition of collagen- or ADP-induced platelet aggregation was observed.Keywords
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