Monoclonal Antibody 4C5 Immunostains Human Melanomas and Inhibits Melanoma Cell Invasion and Metastasis
Open Access
- 15 March 2007
- journal article
- research article
- Published by American Association for Cancer Research (AACR) in Clinical Cancer Research
- Vol. 13 (6) , 1831-1838
- https://doi.org/10.1158/1078-0432.ccr-06-1585
Abstract
Purpose: Tumor cell metastasis constitutes a major problem in the treatment of cancer. Because the cure rate of metastatic tumors is very low, new therapeutic approaches are needed. Heat shock protein 90 (HSP90) is a molecular chaperone that is recognized as a new target for the treatment of cancer. Here, we examine the value of a monoclonal antibody (mAb) against HSP90, mAb 4C5, as a potential marker in malignant melanomas. Moreover, we investigate the possibility to use mAb 4C5 as an inhibitor of melanoma cell invasion and metastasis.Keywords
This publication has 26 references indexed in Scilit:
- Benzoquinone ansamycin heat shock protein 90 inhibitors modulate multiple functions required for tumor angiogenesisMolecular Cancer Therapeutics, 2006
- Phase I Pharmacokinetic and Pharmacodynamic Study of 17-Allylamino, 17-Demethoxygeldanamycin in Patients With Advanced MalignanciesJournal of Clinical Oncology, 2005
- Potent Activity of a Novel Dimeric Heat Shock Protein 90 Inhibitor against Head and Neck Squamous Cell Carcinoma In vitro and In vivoClinical Cancer Research, 2005
- Functional proteomic screens reveal an essential extracellular role for hsp90α in cancer cell invasivenessNature Cell Biology, 2004
- Induction of Hsp90 protein expression in malignant melanomas and melanoma metastasesExperimental Dermatology, 2004
- The 4C5 antigen is associated with Schwann cell migration during development and regeneration of the rat peripheral nervous systemGlia, 2003
- HSP90 as a new therapeutic target for cancer therapy: the story unfoldsExpert Opinion on Biological Therapy, 2002
- Folding of the Glucocorticoid Receptor by the Reconstituted hsp90-based Chaperone MachineryJournal of Biological Chemistry, 1997
- Developmental Expression and Functional Characterization of the 4C5 Antigen in the Postnatal Cerebellar CortexJournal of Neurochemistry, 1995
- Substrate-dependent pH optima of gp63 purified from seven strains of LeishmaniaMolecular and Biochemical Parasitology, 1991