Reaction of Phosphorus Pentasulfide with Organolithiums. AnIn SituReagent for the Preparation of Thiolactams
- 1 January 1987
- journal article
- research article
- Published by Georg Thieme Verlag KG in Synthesis
- Vol. 1987 (02) , 162-164
- https://doi.org/10.1055/s-1987-27871
Abstract
Phosphorus pentasulfide reacts under mild conditions with four equivalents of n-butyllithium, methyllithium or phenyllithium giving solutions in tetrahydrofuran. The new reagents in situ convert lactams to thiolactams and show significant selectivity in the type of reactive lactams.Keywords
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