Serum Vitamin B12Binding Capacity and Oral Contraceptive Hormones
- 1 November 1969
- journal article
- other
- Published by The Endocrine Society in Journal of Clinical Endocrinology & Metabolism
- Vol. 29 (11) , 1425-1428
- https://doi.org/10.1210/jcem-29-11-1425
Abstract
Several serum carrier or binding proteins are increased by pregnancy or contraceptive hormones. Serum vitamin B12 binding capacity is increased during pregnancy. The purpose of this study was to determine if vitamin B12 binding capacity is also increased by oral contraceptive hormones. Serum vitamin B12 binding capacity was measured in 114 female subjects by a modification of the method of Gottlieb et al. Serum vitamin B12 binding capacity was 1606 ± 213 pg/ml (mean ± sd) in 32 normal healthy control subjects, while vitamin B12 binding capacity was 2600 ± 572 pg/ml and 1877 ± 326 pg/ml in the sera of 20 patients, 2–3 days post partum, and 52 women receiving oral contraceptive hormones, respectively Each of these latter means is significantly greater than that for the control group.Keywords
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