Avermectins, New Family of Potent Anthelmintic Agents: Isolation and Chromatographic Properties
Open Access
- 1 March 1979
- journal article
- research article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 15 (3) , 368-371
- https://doi.org/10.1128/aac.15.3.368
Abstract
The avermectins, a family of new anthelmintic agents, were isolated from the mycelia of Streptomyces avermitilis . Four closely related major components and four homologous minor components were separated from the complex. Solvent extraction, solvent partition, and adsorption methods were used to isolate and purify the complex; novel partition chromatography systems using Sephadex LH-20 were used to separate the components. A reverse-phase high-pressure liquid chromatography assay for the quantitative determination of all components was used extensively to monitor the purification methods.This publication has 2 references indexed in Scilit:
- Avermectins, New Family of Potent Anthelmintic Agents: Efficacy of the B 1a ComponentAntimicrobial Agents and Chemotherapy, 1979
- Avermectins, New Family of Potent Anthelmintic Agents: Producing Organism and FermentationAntimicrobial Agents and Chemotherapy, 1979