MODULATION OF TAMOXIFEN-SPECIFIC BINDING SITES AND ESTROGEN RECEPTORS BY ESTRADIOL AND PROGESTERONE IN THE NEONATAL UTERUS OF GUINEA PIG.
- 1 May 1983
- journal article
- other
- Published by The Endocrine Society in Endocrinology
- Vol. 112 (5) , 1871-1873
- https://doi.org/10.1210/endo-112-5-1871
Abstract
Estradiol administration to newborn guinea pigs (30 ng/g body wt) provokes an 84 +/- 10% and 145 +/- 10% (means +/- SE) increase of tamoxifen-specific binding site (site B) in the uterine cytosol and in the 0.6 M KCl nuclear extract, respectively, 48 h after hormone administration. The simultaneous injection of progesterone (15 micrograms/g body wt) with estradiol antagonizes this estrogen-induced increase of site B. Parallel modifications of estrogen receptor are observed following the same estradiol treatment: after translocation to the nuclear fraction, cytoplasmic estrogen receptor is replenished 24 h after hormone administration with a net increase of 60 +/- 10% (mean +/- SE) after 48 h. The increase of estrogen receptor is also antagonized by the simultaneous administration of progesterone. It is concluded that the levels of both tamoxifen-specific binding site and estrogen receptor are modulated by estradiol and progesterone in the neonatal uterus of guinea pig.Keywords
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