STUDIES ON ELECTRICALLY INDUCED THROMBOSIS AND RELATED PHENOMENA

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Abstract
Microampere currents applied with metal electrodes to the mesenteric vessels of mice caused thrombosis, accompanied by electrolyte dissociation and gas formation, When the products of dissociation were removed, clumping, constriction, or thrombosis did not occur. When glass-starch electrodes were used, currents up to 200-[mu]A, applied for 30 minutes, were without effect. Changing to platinum electrodes and applying 50 -[mu]A currents caused, in less than 30 seconds, constriction at the negative pole, clumping, and thrombosis, without constriction at the positive pole. Measurements showed an increase in pH at the negative pole and a decrease at the positive pole. When saline solutions with increased or decreased pH were applied to the vessels, constriction and thrombus formation occurred similar to those produced by electrical current. Experiments were done on heparinized blood in vitro with a U-tube designed to contain the products of electrolysis at each pole. With platinum electrodes a coagulum formed at the positive pole and pH changes occurred at both poles. With glass-starch electrodes these changes did not occur.

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