Effect of Zendium toothpaste on recurrent aphthous stomatitis

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Abstract
A double-blind clinical trial with cross-over was conducted for a period of 12 mo. in 25 patients with recurrent aphthous stomatitis (RAS). The effect of the amyloglucosidase and glucose oxidase containing Zendium toothpaste on the discomfort, number of exacerbations, duration of exacerbation, number of ulcers and number of days with pain caused by RAS was studied. The use of Zendium significantly reduced the sensation of discomfort from RAS as compared to the use of placebo toothpaste (0.025 > P > 0.01). However, the patients were unable to discriminate significantly between Zendium and placebo when asked to choose one of the toothpastes (0.10 > P > 0.05) and no significant differences were demonstrated as far as the above mentioned parameters of disease severity were concerned. Therefore the reducing effect of Zendium containing amyloglucosidase and glucose oxidase on RAS is weak as compared to a similar toothpaste without these enzymes.