Metabolic changes in patients with mitochondrial myopathies and effects of coenzyme Q 10 therapy
- 3 September 1998
- journal article
- research article
- Published by Springer Nature in Zeitschrift für Neurologie
- Vol. 245 (10) , 681-685
- https://doi.org/10.1007/s004150050267
Abstract
We used a standardized bicycle ergometry protocol with a stepwise increasing workload (30–100 W) to evaluate various metabolic factors for the diagnosis and metabolic monitoring of mitochondrial encephalomyopathies. All patients (n = 9) showed pathological venous lactate/pyruvate (L/P) ratios, which normalized in three patients after 6 months of coenzyme Q10 (CoQ) therapy. Thus, the L/P ratio proved to be the clinically most useful parameter in the evaluation and monitoring of mitochondrial diseases, showing higher sensitivity than lactate measurements only. CoQ may exert a favourable effect in some patients with mitochondrial diseases.Keywords
This publication has 0 references indexed in Scilit: