THE EFFECTS OF RENIN AND ANGIOTONIN DURING HEMORRHAGIC HYPOTENSION AND SHOCK

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Abstract
The effects of renin and angiotonin in doses causing a pressor response of 30 mm. Hg, or less, were detd. during two stages of post-hemor-rhagic hypotension and at various periods after reinfusion of the blood, i.e., during development of precipitate or delayed circulatory failure as characteristic of shock. In confirmation of other investigators, it was found that the pressor responses to both of these agents diminished and then disappeared during the prolonged hypotension, but recovered and increased progressively after reinfusion of blood despite the development of circulatory failure. The results failed to support the suggestion that the mechanisms by which renin is activated is implicated in the development of circulatory failure and that the gradual return of response during progressive circulatory failure after reinfusion remains unexplained.

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