K-ras and p16 Aberrations Confer Poor Prognosis in Human Colorectal Cancer
- 15 January 2001
- journal article
- research article
- Published by American Society of Clinical Oncology (ASCO) in Journal of Clinical Oncology
- Vol. 19 (2) , 299-304
- https://doi.org/10.1200/jco.2001.19.2.299
Abstract
PURPOSE: Mutations in the K-ras gene are frequent in human cancer. ras activation in primary cells results in a cellular senescence phenotype that is precluded by inactivation of p16. At the clinic...Keywords
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