Paraoxon: Effects on Rat Brain Cholinesterase and on Growth Hormone and Prolactin of Pituitary
- 17 March 1972
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 175 (4027) , 1256-1258
- https://doi.org/10.1126/science.175.4027.1256
Abstract
Cholinesterase activity of brain and content of growth hormone and prolactin in the pituitary were compared after short-term (3 days) and long-term (14 days) treatment with paraoxon in male and female rats. Within 3 days cholinesterase activity was reduced to between 5 and 15 percent of that in controls. The content of growth hormone in the pituitary was increased in long-term experiments by 50 percent. This increase in paraoxon-treated animals suggests a possible role of a cholinergic mechanism in the regulation of growth hormone secretion.Keywords
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