Effects of Angiotensin Infusion on the Isolated Rabbit Kidney

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Abstract
Summary Isolated rabbit kidneys were perfused, at a constant pressure of 97.1 ± 3.0 mm Hg, with a suspension of 40 vol% rabbit erythrocytes in Tyrode's solution, to which 4 g% bovine albumin had been added. When, after a control period of 60 min, angiotensin II-amide, in a dose of 0.1 ngm-1; min-1 was infused into the perfusion system for 10 min, GFR and FF increased during the infusion and fell to the preceding levels after it had been stopped. Urine volume and urinary sodium excretion were only slightly elevated. Absolute sodium reabsorption rose within 2 min after beginning the infusion, but fell below the initial value after angiotensin was turned off. It is concluded that constriction of the efferent arterioles is responsible for the increase in GFR and FF, and that variations in sodium reabsorption may be the consequence of changes in renal hemodynamics rather than in tubular function.

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