SALSALATE FOR ARTHRITIS - A CLINICAL-EVALUATION

  • 1 January 1984
    • journal article
    • research article
    • Vol. 6  (4) , 388-403
Abstract
In an open-label trial, 182 patients with common forms of arthritis were treated with 3 g of salsalate daily (2 750-mg tablets twice daily) for 15 days. Before entering the study, these patients had received a wide variety of antarthritic medications. Five indices of disease severity (pain, stiffness, joint swelling, limitation of motion and disability) were evaluated before and after salsalate therapy; the incidence of side effects was tabulated before and after treatment; and patient compliance with the salsalate regimen was assessed. A reduction in disease symptoms was noted in 79% of the treated patients. Median improvement, measured on a summary index, was 47%. The incidence of side effects experienced with previous therapy was reduced by 65% during salsalate administration. Patient compliance with the regimen was > 95%. Salsalate was evidently effective and safe in ameliorating the symptoms of arthritic disease. The convenient twice-daily dosage regimen makes this drug particularly suitable for chronic use.

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