LIVER ULTRASTRUCTURE IN PSORIATICS RELATED TO METHOTREXATE THERAPY .2. FINDINGS IN BILE-DUCTS FROM 11 METHOTREXATE TREATED PSORIATICS AND 2 CONTROLS

  • 1 January 1977
    • journal article
    • research article
    • Vol. 85  (6) , 801-811
Abstract
To determine what damage occurred in bile ducts of psoriatics receiving methotrexate (MTX) therapy liver biopsies from 11 patients were studied with the light microscope and EM and compared with normal material. Thick sections (1 .mu.m) showed light and dark cells is biliary epithelium and lipofuscin granules. At the ultrastructural level these were confirmed. The lumen of bile ducts contained debris. Microvilli were decreased in number, and damaged forms appeared. Damage to the biliary epithelial mitochondria was widespread, and there were foci of intracellular edema. The Golgi apparatus was hypertrophied and dilated. Atrophic cells were seen. Lateral intercellular spaces were dilated and contained debris, and the basement membrane showed zones of duplication. Similar changes were found in ducts of Hering.

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