A Convenient Synthesis Of Substituted 3-Pyrrolin-2-ones from α-Cetols
- 1 November 1993
- journal article
- research article
- Published by Taylor & Francis in Synthetic Communications
- Vol. 23 (19) , 2631-2638
- https://doi.org/10.1080/00397919308013792
Abstract
A simple and efficient method for the preparation of the title compounds is described from cyanoacetamides and 3-hydroxy-3-methyl-2-butanone in the presence of sodium ethylate at room temperature. The 3-carboxamido-N-alkyl-4, 5, 5-trimethyl-5-dihy dro-2H-pyrrol-2-ones lead to unsaturated derivatives by condensation with aldehydes, while hydrogenation give rise to the corresponding pyrrolidin-2-ones.Keywords
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