Increased Activity of Plasma Cholesteryl Ester Transfer Protein in Children with End-Stage Renal Disease Receiving Continuous Ambulatory Peritoneal Dialysis
- 1 January 1996
- journal article
- research article
- Published by S. Karger AG in Nephron
- Vol. 72 (2) , 231-236
- https://doi.org/10.1159/000188847
Abstract
The activity of cholesteryl ester transfer protein (CETP) was assayed in sera of children and adolescents on continuous ambulatory peritoneal dialysis (CAPD) by coincubating lipoprotein-deficient samples with exogenous donor and acceptor lipoproteins. Serum levels of triglycerides, total cholesterol, low-density lipoprotein cholesterol and apolipoprotein B and apoliproprotein B/ apolipoprotein A1 ratio were increased, while the high-density lipoprotein cholesterol level was decreased. The CETP activity in children on CAPD exceeded that in either adults or control children, and was correlated with low-density lipoprotein cholesterol, apolipoprotein B, and total cholesterol/ high-density lipoprotein cholesterol, low-density lipoprotein cholesterol/high-density lipoprotein cholesterol, and apolipoprotein B/apolipoprotein A1 ratios. The CETP activity in CAPD patients may be due to increased synthesis in response to a protein loss in the dialysis fluid and may exacerbate atherosclerosis.Keywords
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