Heterozygosity at Gm loci associated with humoral immunity to osteosarcoma.
Open Access
- 1 April 1982
- journal article
- research article
- Published by Rockefeller University Press in The Journal of Experimental Medicine
- Vol. 155 (4) , 1228-1232
- https://doi.org/10.1084/jem.155.4.1228
Abstract
Serum samples from 50 Caucasian patients with osteosarcoma were tested for the presence of antibodies to osteosarcoma-associated antigens (OSAA) and typed for nine Gm markers. A highly significant association was found between Gm 3;5,13,14 and unresponsiveness to OSAA, and between 1,3,17;5,13,14,21 and responsiveness to OSAA. These results suggest the existence of complementary immune response genes which in the heterozygous condition permit a response to OSAA.This publication has 23 references indexed in Scilit:
- Immunologic studies in contacts of osteosarcoma in humans and animalsNature, 1977
- A membrane antigen common to human cancer and fetal brain tissues.1976
- Disease Susceptibility Genes ‐ their Identification by Multiple Case Family StudiesTissue Antigens, 1976
- ISOLATION AND PARTIAL-PURIFICATION OF PLASMA MEMBRANE-ASSOCIATED ANTIGENS FROM HUMAN OSTEOSARCOMA (TE-85) CELLS IN TISSUE-CULTURE1976
- Tumor-specific cell-mediated immunity in household contacts of cancer patients..Journal of Clinical Investigation, 1975
- The investigation of linkage between a quantitative trait and a marker locusBehavior Genetics, 1972
- Serogenetic investigations on malignant melanomas with reference to the incidence of AB0 system, Rh system, Gm, Inv, Hp and Gc systemsHuman Genetics, 1972
- Cultivation in vitro of cells derived from a human osteosarcomaCancer, 1971
- Immunologic studies of human sarcomas: Additional evidence suggesting an associated sarcoma virusCancer, 1970
- A New Rapid Method for Genetic Typing of Human ImmunoglobulinsThe Journal of Immunology, 1968