INTERFERON INDUCTION IN DOGS

  • 1 January 1979
    • journal article
    • research article
    • Vol. 40  (3) , 356-361
Abstract
A synthetic complex of poly (IC) with poly-L-lysine and CM cellulose (poly ICLC) and UV-inactivated Newcastle disease virus B-1 strain were used to induce interferon production in dogs. Several criteria were used for interferon specificity. The interferon response depended on dosage and route of inoculation. Serum interferon concentrations usually reached a peak by 8 h after inoculation (AI), rapidly declined thereafter and were nondetectable in most instances at 24 h AI. Dogs responded less to interferon inducers when re-inoculated 2 days after primary induction. The interferon response was biphasic (2 and 8 h AI) when re-inoculated 1 wk after primary inoculation. Re-inoculation 2 wk after primary inoculation simulated the 1st response. Both inducers caused severe lymphopenia in dogs. The toxic side effects would limit clinical use (in dogs) in poly ICLC but not UV-inactivated Newcastle disease virus.