CYCLICAL CHANGES IN SUSCEPTIBILITY OF A MYELOMA TUMOR (LPC-1) TO IMMUNE DESTRUCTION .1. CHANGES IN REACTIVITY WITH CYTOTOXIC LYMPHOCYTE-T AND ANTI-H-2D SERA

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  • 1 January 1979
    • journal article
    • research article
    • Vol. 122  (3) , 954-958
Abstract
Of 6 transplantable ascites tumors of BALB/c mice, 1 became periodically resistant to cytotoxic T [thymus-derived] lymphocytes (CTL). About 12 days after LPC-1 was transplanted it became resistant to lysis by allogenic CTL (anti-H-2d) and by CTL directed to trinitrophenyl groups or minor histocompatibility antigens. Susceptibility to lysis by all of these CTL was regained within 2-4 days after transfer of the resistant cells to a fresh BALB/c host. These changes were recurrent: in each transplantation cycle the early LPC-1 cells were susceptible and the late cells were resistant to CTL. Analyses with antisera (B10 anti-B10.D2) showed that the serologically recognized products of the H-2d haplotype were reduced about 10-fold on the LPC-1 cells that were resistant to CTL.