Medulloblastoma in infants and children: computed tomographic follow-up after treatment.

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Abstract
Thirty-six proven cases of medulloblastoma were reviewed by serial CT [computed tomography] follow-up examinations from 4 mo. to 10 yr, 2 mo. after the initial diagnosis, with a mean follow-up time of 3 yr, 9 mo. The children ranged in age from 10 mo.-16 yr, 7 mo. at the time of follow-up. The tumor recurred at the primary site in 20 cases (56%). Leptomeningeal metastasis was demonstrated on CT in 14 cases (39%); 7 of these patients also presented with solid subarachnoid metastases; 13 patients (36%) showed evidence of severe brain atrophy, which was confined to the posterior fossa in 7. Calcification resulting from mineralizing microangiopathy developed in 5 cases (14%), including 3 patients who had extensive dystrophic calcification in the corticomedullary junction and the deep-seated nuclei of the cerebrum and cerebellum. Only 1 case of leukoencephalopathy was observed. The patterns of tumor recurrence in the posterior fossa that is severely deformed by surgery and other treatment modalities and leptomeningeal spread of tumor are discussed.

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