Effects of Acute Administration of 5-Methoxy-N,N-dimethyltryptamine upon the Latency and Duration of Post-decapitation Convulsions

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Abstract
The effect of acute administration of rats with the 5-hydroxytryptamine (5-HT) agonist drug 5-methoxy-N,N-dimethyltryptamine on the convulsions released by decapitation was examined. The postsynaptic agonist, 5-methoxy-N,N-dimethyltryptamine, prolonged the latency and duration from the 0.5 mg/kg dose upwards. Methergoline, 2.0 mg/kg intraperitoneally injected immediately prior to 5-methoxy-N,N-dimethyl-tryptamine, caused some considerable blockade of the effects of the 5-HT agonist on post-decapitation convulsions (PDC's). Long-term p-chloroamphetamine (2 × 10 mg/kg) and p-chlorophenylalanine (1 × 300 mg/kg) did not antagonise the 5-methoxy-N,N-dimethyltryptamine induced changes of PDC's but, by themselves, prolonged PDC duration. The utility of the 5-methoxy-N,N-dimethyltryptamine-PDC method for studying 5-HT receptor mechanisms may be worth considering.